Pinky and the Brain

'Pinky and the Brain' was the cartoon spin-off to 'Animaniacs' and ran from 1995-1998. "Pinky and the Brain were a duo of lab rats, one goofy (Pinky), one bent on taking over the world (Brain). The Brain's best-laid plans always went astray, but he kept trying with Wile E. Coyote-like persistence" [http://www.tv.com/shows/animaniacs/].

Like Animaniacs, 'Pinky and the Brain' also parodied popular culture including a mock of Disney's 'Winnit the Pooh' in 'Brainy the Pooh'. They could also be placed in any time ear; whether it be modern times )appearing in an episode of 'The Real World', the wild west fighting for hippy freedom or in the French renascence meeting (and impersonating) Napoleon.

Much like the Roadrunner Looney Tunes cartoons, 'Pinky and the Brain' followed 2 lab mice (living in ACME labs) who were determined to take over the world every episode despite failing in every attempt thus far. Every episode, the Brain would think of another hair-brained scheme to try and take possession of the Earth - my favourite being building another Earth out of Papier-Mache and luring everyone from the real planet Earth to it using free t-shirts in "It's only a paper world".

"It's only a paper world" - screen shot

Sources:
http://www.tv.com/shows/animaniacs/